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Graphite prices have experienced volatility recently due to bottlenecks in demand for electric vehicles.

One major factor experts are watching right now is the trade war between China and the US.

China introduced export restrictions on certain graphite products on December 1, 2023, making it a requirement for Chinese exporters to apply for special permits to ship the material to global markets. In July 2024, the Trump administration in the US announced it would raise tariffs on battery-grade graphite imports from China to 93.5 percent.

Another trend shaping the graphite market in 2025 has been increasing substitution of natural graphite with synthetic in battery anode production; this comes in response to Chinese exports restrictions and US tariffs on natural graphite.

This has led to much lower prices for natural graphite, and against that backdrop, many Canadian graphite stocks have trended down. However, several graphite-focused companies have seen strong performances this year.

Below is a look at the year’s best-performing graphite stocks on the TSXV and CSE; TSX companies were considered, but none made the cut this time. Data was obtained on July 29, 2025, using TradingView’s stock screener, and all companies listed had market caps above C$10 million at that time. Read on to learn more about their work this year.

1. HydroGraph Clean Power (CSE:HG)

Year-to-date gain: 384.21 percent
Market cap: C$282.81 million
Share price: C$0.99

HydroGraph Clean Power produces cost-effective, high-purity graphene, hydrogen and other strategic nanomaterials.

Graphene, a pure carbon material extracted from graphite, has myriad potential applications in industries such as transport, solar cells, medicine, electronics, energy, defense and desalination. HydroGraph has an exclusive license from Kansas State University to produce graphene and hydrogen through the organization’s patented detonation process.

Much of HydroGraph’s news flow in 2025 has centered on strategic partnerships.

Results from a research study conducted with Arizona State University were released in January, demonstrating that the company’s HydroGraph’s Fractal Graphene is well suited for ultra-high-performance concretes and 3D-printed structures. In February, HydroGraph announced a technical collaboration with an unnamed global leader in synthetic fiber manufacturing to assess the potential of its graphene technology in high-performance fiber applications.

The following month, HydroGraph shared the launch of a line of advanced graphene dispersions developed in collaboration with battery materials and testing services company NEI. The products have the potential to be used to produce high-performance electrodes for use in energy storage solutions.

The company signed a letter of intent in April that could lead to a leading North American industrial gas supplier providing it with access to large volumes of high-purity acetylene. This is an essential material in HydroGraph’s patented detonation synthesis process. Acquiring this feedstock will help the firm advance its plans to build a new graphene production facility in Texas with the capacity to produce over 350 metric tons of graphene annually.

HydroGraph launched its Compounding Partner Program in July with the goal of attaining commercial-scale production of its high-performance Fractal Graphene in thermoplastics. According to the company, initial certified partners are testing new formulations in the automotive and packaging sectors.

After trading in a range of C$0.22 to C$0.35 for much of the year, shares of HydroGraph jumped nearly 300 percent in a matter of days to reach a year-to-date high of C$0.99 on July 29.

2. Black Swan Graphene (TSXV:SWAN)

Year-to-date gain: 107.35 percent
Market cap: C$60.02 million
Share price: C$1.41

Black Swan Graphene describes itself as an emerging powerhouse in the bulk graphene business.

The company is a spinout of Mason Resources (TSXV:LLG,OTCQX:MGPHF), which owns the Uatnan graphite project in Québec and holds a 39 percent stake in Black Swan. Graphite from Uatnan is used to supply Black Swan.

UK-based global chemicals manufacturer Thomas Swan & Co. holds a 15 percent interest in Black Swan, and brings a portfolio of patents and intellectual property related to graphene production. Through this partnership, Black Swan is building out a fully integrated supply chain of mine-to-graphene products.

Black Swan’s share price traded sideways for much of the year before benefiting greatly from a summer surge. Shares of Black Swan reached their highest year-to-date price of C$1.52 on July 23.

This followed a series of positive news items concerning progress on increasing commercial output. On June 3, Black Swan announced the installation of an additional production unit at its operational facility in the UK. It is working to more than triple its annual production capacity from 40 metric tons of high-quality graphene to 140 metric tons.

Later in the month, the company signed a non-exclusive distribution and sales agreement with Indian specialty materials and polymers supplier METCO Resources. The agreement will allow METCO to “distribute and promote Black Swan’s graphene nanoplatelets and GEM advanced masterbatch products to customers across India’s industrial, packaging, automotive, and construction sectors,” as per a press release.

Black Swan made another key announcement in the following month. On July 9, the market learned the company had secured a US patent for its breakthrough continuous graphene production process.

3. Focus Graphite Advanced Materials (TSXV:FMS)

Year-to-date gain: 100 percent
Market cap: C$12.26 million
Share price: C$0.135

Focus Graphite Advanced Materials is both a graphite miner and a battery technology company. Its wholly owned flagship Lac Knife high-grade crystalline flake graphite project is located in Northeastern Québec.

With a completed feasibility study, Lac Knife is one of North America’s most advanced graphite deposits. The company also holds Lac Tétépisca, the highest-purity graphite project in Québec.

In terms of battery technologies, Focus Graphite has a patent-pending proprietary silicone-enhanced spheroidized graphite technology that is designed to enhance battery performance and efficiency.

In late May, definition drilling at Lac Tétépisca led to an extension of the strike length of the mineralized zone to over 6 kilometers, while preliminary metallurgical testing confirmed the quality of the project’s flake graphite.

In mid-June, the company said thermal purification testing on Lac Knife flake graphite completed by American Energy Technologies Company had resulted in refined concentrate to a purity level of 99.999 percent carbon.

“This milestone underscores Focus Graphite’s potential to supply ultra-high-purity graphite material for nuclear energy applications, a market historically dominated by synthetic graphite and limited to a small cohort of qualifying producers,” states the company’s press release.

Shares of Focus Graphite hit their highest year-to-date value of C$0.17 on June 17.

Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

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The Democratic National Committee slammed Vice President JD Vance for fishing on a private lake with British Foreign Secretary David Lammy during Vance’s official trip to the United Kingdom. 

Republicans were quick to respond to what appears to be the latest in a series of attacks by Democrats against the vice president over outdoor activities and family outings Vance mixes in during his rigorous official travel schedule. 

The DNC War Room issued a press release Wednesday titled ‘VACATION VANCE AT IT AGAIN: Vance Fished ‘Illegally’ With UK Foreign Secretary While Americans Drown in Sky-High Costs.’ 

Vance and Lammy met at the foreign secretary’s official country residence, known as Chevening House, located south of London, on Friday for talks centered on the Israel-Hamas conflict and Russia’s war in Ukraine. 

They went fishing on the estate grounds before their scheduled meeting. Vance briefly joked to reporters that theone strain on the special relationship’ he has with Lammy ‘is that all of my kids caught a fish, but the foreign secretary did not.’ The vice president soon delved into more serious topics, including telling reporters that, unlike the U.K., the United States has ‘no plans to recognize a Palestinian state’ given the ‘lack of a functional government’ in Gaza. 

Their meeting came a week before President Donald Trump’s upcoming high-stakes meeting with Russian President Vladimir Putin in Alaska. 

In its release on Wednesday, the DNC charged, ‘Vance is living it up on his summer holiday — on the taxpayers’ dime — all while working families face sky-high inflation and the largest cuts to health care and food assistance in American history.’ 

Kiersten Pels, a spokeswoman for the Republican National Committee, said in a statement to Fox News Digital, ‘The DNC’s donors are OK with funding press releases on a fishing rod license? They might want to pull their money out now before the last of it vanishes down the drain.’ 

U.K. outlets reported that Lammy did not buy a valid fishing license before the outing with Vance. In a statement to Sky News, the British Foreign Office said the secretary ‘has written to the Environment Agency over an administrative oversight that meant the appropriate licences had not been acquired for fishing on a private lake as part of a diplomatic engagement at Chevening House last week.’ 

The agency reportedly requires rod licenses for fishing of freshwater species in England and Wales for people 13 or above. 

During his visit to the U.K. last week, Vance also gave a brief address to U.S. troops stationed at RAF Fairford in Gloucestershire. 

The DNC claimed Vance spoke to troops ‘for only six minutes before returning to his $10,000 per week luxury Cotswolds manor.’

The release also took issue with Vance allegedly ‘using public resources’ earlier this month ‘so he could do boating on his birthday.’ 

‘Vance fished ‘illegally’ in the United Kingdom, potentially costing the foreign secretary a £2,000 fine. Vance even had former Chancellor George Osborne plan his vacation’s social agenda, including relaxing in the ‘Hamptons of the UK,’’ the release said.

The DNC further charged that Trump and Vance ‘ripped away health care from 17 million Americans, slashed food assistance for over 22 million families, and unleashed economic chaos on the American people —  all to give their billionaire friends and donors another round of massive tax handouts.’ 

‘While working families struggle to get by, it’s clear where Vance’s loyalties lie — and it’s not with them,’ the DNC wrote. 

The latest attack comes after Democratic California Gov. Gavin Newsom, a potential 2028 presidential contender, bemoaned Vance’s recent visit to Disneyland with his children. 

‘Hope you enjoy your family time,’ Newsom wrote on social media. ‘The families you’re tearing apart certainly won’t.’

In response, Vance wrote, ‘Had a great time, thanks.’ 

Critics also attempted to paint Vance as entitled after the vice president’s security detail had an Ohio river’s water levels raised to accommodate a kayaking trip he and his family took to celebrate his 41st birthday. The U.S. Secret Service made the request to the U.S. Army Corps of Engineers so that motorized watercraft and emergency personnel could operate safely.

Before his political career, Vance notably penned an autobiography, ‘Hillbilly Elegy,’ which describes how he was raised by an opioid-addicted mother in Appalachia, joined the Marines and found success at Yale Law School. 

In a recent interview on ‘The Katie Miller Podcast,’ Vance revealed that reserving ‘sacred time’ with family allows him to balance his official duties with the duties of being a husband and father.  

‘It’s possible to do it even in my job,’ he said. ‘Yes, if like a war breaks out, then sometimes you have to cancel even the sacred time. But we’ve been pretty good about making sure that I have at least a couple of hours with my family every single day.’ 

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President Donald Trump indicated Wednesday that he would meet with the top congressional Democrats ahead of the looming government funding deadline, but said he didn’t believe it would go well.

Lawmakers in the House and Senate are currently away from Washington, D.C., in their respective districts and states, but the Sept. 30 deadline to prevent a partial government shutdown will be just a handful of weeks away when they return after Labor Day.

And there is a brewing tension between Republicans and Democrats over just how the looming government funding fight will shake out.

Trump, during a press conference where he announced a slate of Kennedy Center honorees, said he would meet with Senate Minority Leader Chuck Schumer, D-N.Y., and House Minority Leader Hakeem Jeffries, D-N.Y., before the deadline.  

‘But it’s almost a waste of time to meet, because they never approve anything,’ Trump added.

‘I don’t believe anybody is capable of making a deal with these people,’ he continued. ‘They have gone crazy.’

Fox News Digital reached out to Schumer and Jeffries for comment but did not immediately hear back.

Lawmakers must pass the dozen spending bills needed to fund the government to avert a partial shutdown, but that process, known as regular order, has not happened in decades.

While Senate Majority Leader John Thune, R-S.D., has made clear he wants to pass spending bills, and the Senate did indeed pass a trio of funding measures before leaving town, Congress will likely again turn to a short-term government funding extension, known as a continuing resolution (CR).

However, any CR must pass muster with Senate Democrats, given that the legislation has to pass through the upper chamber’s 60-vote threshold.

And congressional Democrats have a bitter taste left in their mouths after Republicans rammed through Trump’s $9 billion clawback package, which included deep cuts to NPR, PBS and foreign aid. They warned that any more attempts to claw back congressionally approved funding on a partisan basis could doom government funding negotiations.

Ahead of the vote to pass three spending bills in the Senate, which included funding for military construction and Veterans Affairs, agriculture and the Food and Drug Administration (FDA), and the legislative branch, congressional Democrats vowed that they would play ball – as long as the appropriations process was bipartisan.

‘We all want to pursue a bipartisan, bicameral appropriations process,’ Schumer said at the time. ‘That’s how it’s always been done, successfully, and we believe that, however, the Republicans are making it extremely difficult to do that.’

Earlier this year, Schumer briefly flirted with a government shutdown. However, he eventually relented and voted with Republicans to keep the lights on in Washington, and in the process ignited a firestorm within his own party over his ability as leader of the Senate Democratic caucus.

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President Donald Trump threatened ‘very severe consequences’ for Russia if President Vladimir Putin doesn’t agree to end the war in Ukraine after their meeting in Alaska on Friday. 

Trump issued the warning Wednesday as he is preparing for a sit-down with Putin in Anchorage. 

‘Yes, they will. There will be consequences,’ Trump said in response to a reporter’s question on the topic. The president then refused to elaborate on what the punishment would be. 

‘I don’t have to say. There will be very severe consequences,’ he added. 

Trump later appeared to cast doubt on whether he could convince Putin to stop bombing Ukrainian civilians. 

‘I’ll tell you what. I’ve had that conversation with him. I’ve had a lot of good conversations with him then I go home and I see that a rocket hit a nursing home or a rocket hit an apartment building, and people are laying dead in the streets,’ Trump said. 

‘So, I guess the answer to that is no, because I’ve had this conversation. I want to end the war. It’s Biden’s war, but I want to end it. I’ll be very proud to end this war, along with the five other wars I ended. But, I guess the answer to that is probably no,’ Trump continued. 

Ukrainian President Volodymyr Zelenskyy also said Wednesday that there is ‘no sign’ that Russia is preparing to end the war in Ukraine. 

‘At present, there is no sign that the Russians are preparing to end the war. Our coordinated efforts and joint actions – of Ukraine, the United States, Europe, and all countries that seek peace – can definitely compel Russia to make peace,’ Zelenskyy said on X. 

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The Trump administration is announcing the launch of a new tool it says will be instrumental in enabling agencies across the federal government to efficiently implement artificial intelligence at scale and take a major step forward rolling out the president’s ‘AI Action Plan.’

Trump’s U.S. General Services Administration (GSA) said on Thursday it has launched USAi, a tool the agency describes as a ‘secure generative artificial intelligence evaluation suite that enables federal agencies to experiment with and adopt artificial intelligence at scale—faster, safer, and at no cost to them.’

The agency says that the platform, available starting Thursday at 10 a.m. through USAi.gov, gives government users access to ‘powerful’ tools like chat-based AI, code generation and document summarization with the goal of ‘supercharging employee productivity.’

‘USAi isn’t just another tool, it’s infrastructure for America’s AI future,’ GSA Chief Information Officer David Shive explained. ‘USAi helps the government cut costs, improve efficiency, and deliver better services to the public, while maintaining the trust and security the American people expect.’

GSA Deputy Administrator Stephen Ehikian told Fox News Digital that this latest application is an ‘on ramp’ to A.I. that will be the ‘tip of the spear’ on the A.I. front similar to the way GSA previously implemented the cloud. 

The Trump administration rolled out its A.I. Action Plan in July after Trump ordered the federal government in January to develop a plan of action for artificial intelligence in order to ‘solidify our position as the global leader in AI and secure a brighter future for all Americans.’ 

Trump has made U.S. A.I. growth a cornerstone of his administration, such as notching multi-billion deals with high-tech firms such as Oracle and OpenAI for the Stargate project, which is an effort to launch large data centers in the U.S, as well as a $90 billion energy and tech investment deal specifically for the state of Pennsylvania to make it the U.S. hub for AI. 

‘USAi means more than access—it’s about delivering a competitive advantage to the American people,’ GSA Deputy Administrator Stephen Ehikian said in press release.

‘The launch of USAi shows how GSA is translating President Trump’s AI strategy into action and accelerating AI adoption across government. USAi will put mission-ready tools directly into the hands of agencies to modernize faster, boost security, and lead globally.’

The A.I. Action Plan includes a three-pillar approach focused on American workers, free speech and protecting U.S.-built technologies. 

‘We want to center America’s workers, and make sure they benefit from AI,’ A.I. and crypto czar David Sacks told the media in July when details of the A.I. plan were made public. 

‘The second is that we believe that AI systems should be free of ideological bias and not be designed to pursue socially engineered agendas,’ Sacks said. ‘And so we have a number of proposals there on how to make sure that AI remains truth-seeking and trustworthy. And then the third principle that cuts across the pillars is that we believe we have to prevent our advanced technologies from being misused or stolen by malicious actors. And we also have to monitor for emerging and unforeseen risks from AI.’

Advancing the federal government’s use of A.I. and expanding employee access are core to the GSA’s efforts to fulfill Trump’s directive to preserve U.S. leadership in the global technology race, GSA Commissioner Josh Gruenbaum explained to Fox Digital in an interview earlier this month. 

‘As we kind of examined the President’s AI action plan, heard the call to action of, ‘Hey, this is a race, and we are going to win this race.’ From our perspective, all that meant, synonymously, was widespread adoption,’ he told Fox Digital of delivering AI to federal employees. 

The rollout of the USAi tool follows GSA announcing earlier in August that OpenAI’s ChatGPT Enterprise is now available to all federal agencies to incorporate into their workflow at $1 per agency. The deal with OpenAI, the tech company behind ChatGPT, is part of GSA’s OneGov Strategy that aims to modernize ‘how the federal government purchases goods and services’ under the Trump administration. 

GSA also notched another deal with A.I. company Anthropic this month providing all three branches of government access to large language model Claude. 

Gruenbaum told Fox News Digital that Thursday’s announcement will be critical for agencies for creating efficiencies to help turn the federal workforce into ‘the most nimble, smart, efficient, agile, and agentically tech-forward workforce out there so that this country can continue to compete and win the AI race.’

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President Donald Trump has pledged to protect and preserve Social Security, and I am honored to lead the agency as Commissioner at such a pivotal moment. My vision is straightforward: a Social Security Administration that is easier to access, faster to respond, and better prepared to meet the challenges of tomorrow. That vision is rooted in our commitment to public service and grounded in the belief that government can and should work for everyone.

Since taking office, I have focused on modernizing operations; investing in our workforce; eliminating fraud, waste, and abuse; and improving how we serve the public, whether online, over the phone, or in person. 

Social Security is not a program of the past; it is a promise to future generations. 

We have expanded our digital tools to provide more services from the convenience of people’s homes. We have taken steps to reduce wait times, enhance security, and make it easier to navigate our programs. All the while ensuring we pay benefits accurately to those who are eligible to receive them.

We have also added support and removed roadblocks for our frontline employees with updated tools, technology, and processes, so they can deliver efficient, accurate, and compassionate service to the American people every day.

In my first 100 days as Commissioner, SSA has made significant progress, improving customer experience: reducing the average wait time on the national 800 number from 30 minutes last year to single digits last month; implementing new phone systems to enable 90% of calls to be handled via self-service or convenient callbacks; shortening field office wait times by 30%; eliminating 29 hours of weekly downtime for my Social Security to allow 24/7 online management of benefits; decreasing Disability hearing wait times by 60 days, reaching historic lows; and, sending over 3.1 million payments totaling $17 billion to eligible beneficiaries five months ahead of schedule under the Social Security Fairness Act.

We have a clear path to achieving operational excellence and providing best-in-class service. Under President Trump’s leadership, I have charted a new course that strengthens service delivery and secures the integrity and efficiency of our systems. We are modernizing the underlying infrastructure that supports our work so that the agency is not only keeping up with the pace of change but leading the way in service innovation.

As we celebrate this 90th anniversary, we must also keep our eyes firmly on the future. Social Security is not a program of the past; it is a promise to future generations. 

Young Americans entering the workforce today deserve the same sense of security their parents and grandparents had. Maintaining that trust will require thoughtful innovation and a shared commitment to protecting the integrity and solvency of the program.

As we look to the century ahead, President Trump remains committed to ensuring that Social Security is as strong, effective, and enduring for our children and grandchildren as it has been for the generations before them.

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The NASDAQ Biotechnology Index (INDEXNASDAQ:NBI) is still trading at three-year highs, despite current market volatility, in response to breakthrough innovations and increased deals involving biotech stocks listed on the NASDAQ.

After dropping to a low of 3,637.05 in October 2023, the index climbed to a nearly three year peak of 4,954.813 on September 19, 2024. While the index had pulled back to 4,530.69 as of August 5, 2025, further growth could be in store in the future.

According to a Towards Healthcare analyst report, the global biotech market is expected to grow at a compound annual growth rate of 12.5 percent from now to 2034, reaching a valuation of US$5.04 trillion.

Driving that growth will be favorable government policies, investment in the sector, increased demand for synthetic biology and a rise in chronic disorders such as cancer, heart disease and hypertension.

The top NASDAQ biotech stocks have seen sizeable share price increases over the past year. For those interested in investing in biotech companies, the best-performing small-cap biotech stocks are outlined below.

Data was gathered on August 5, 2025, using TradingView’s stock screener. Small-cap biotech stocks with market caps between US$50 million and US$500 million at that time were considered for this list.

1. Tiziana Life Sciences (NASDAQ:TLSA)

Year-to-date gain: 227.8 percent
Market cap: US$256.36 million
Share price: US$2.26

Tiziana Life Sciences is a clinical-stage biopharma which is developing therapies for autoimmune and inflammatory diseases, degenerative diseases, and cancer-related to the liver. Its pipeline of candidates is built on its patent drug delivery technology that provides a possible alternative to intravenous delivery. Tiziana’s lead candidate is intranasal foralumab, a fully human anti-CD3 monoclonal antibody.

Tiziana Life Sciences shares hit US$1.69 on March 7 after the company filed its investigational new drug application to the US Food and Drug Administration (FDA) for a Phase 2 clinical trial in amyotrophic lateral sclerosis (ALS), which is supported by the ALS Association. However, by early April that value had fallen back to US$0.78 per share.

A series of positive news flow later in the spring helped to give Tiziana shares another boost. In April, John Hopkins University and the University of Massachusetts commenced dosing of the biotech company’s intranasal foralumab in Phase 2 trials for patients with non-active secondary progressive multiple sclerosis. On May 7, the company shared positive results from the use of its lead candidate in improving the quality of life for patients with that form of multiple sclerosis.

Tiziana is also studying the use of intranasal foralumab for treating moderate Alzheimer’s disease. On May 9, it announced that PET scans of a patient with moderate Alzheimer’s showed a significant reduction in microglia activation associated with neuroinflammation after three months of treatment.

Shares of Tiziana reached US$1.62 on May 13.

On July 21, the company announced an ‘unexpected discovery’ in its findings of an immunologic analysis of the patient with Alzheimer’s disease.

‘In an unexpected discovery, the analysis revealed an increase in phagocytosis markers in classical monocytes, suggesting that nasal foralumab may enhance their ability to clear amyloid plaques,’ the press release states. ‘This unexpected effect may open new avenues for treating Alzheimer’s Disease by targeting both inflammation and amyloid accumulation.’

Tiziana’s share price climbed through the remainder of the month, hitting a year-to-date high of US$2.50 on July 31.

2. Palvella Therapeutics (NASDAQ:PVLA)

Year-to-date gain: 224.98 percent
Market cap: US$416.08 million
Share price: US$37.64

Palvella Therapeutics is a clinical-stage biopharma developing treatments targeting rare genetic skin diseases for which there are no FDA-approved therapies. The company’s product pipeline centers on its patented QTORIN platform, which has an initial focus on rare genetic skin diseases.

Its lead product candidate, QTORIN rapamycin, is currently in a Phase 2 clinical trial in cutaneous venous malformations, and a Phase 3 clinical trial in microcystic lymphatic malformations (LM). QTORIN rapamycin has been granted breakthrough therapy designation, orphan drug designation and fast track designation from the FDA for the treatment of microcystic LMs.

After starting the year at US$12.00, shares of Palvella had surged to US$20.99 by February 18. About a week earlier, the company had shared plans to expand the Phase 3 trial to include pediatric patients from three to five years of age. That momentum in Palvella’s share price continued to rally to US$29 per share on March 13.

June produced a number of significant milestones for Palvella. On June 9, the company received initial proceedings from a grant issued by the FDA Office of Orphan Products Development for its Phase 3 trial, and on June 23, it completed enrollment for the trial with 51 subjects, 25 percent over its target. The company closed out the month with news it was added to the broad-market Russell 3000 Index and the Russell 2000 Index.

The company said it remains on track to deliver top-line Phase 3 data in Q1 2026 to support its planned new drug application submission later that year.

While the company didn’t release news in July, Palvella Therapeutics’ share price climbed significantly through the month to hit a year-to-date high of US$39.87 on July 28.

3. OKYO Pharma (NASDAQ:OKYO)

Year-to-date gain: 163.03 percent
Market cap: US$117.35 million
Share price: US$3.13

OKYO Pharma is a clinical-stage biopharma developing therapies for the treatment of neuropathic corneal pain and dry eye disease. Its lead candidate is urcosimod, a non-steroidal anti-inflammatory and non-opioid analgesic.

So far in 2025, the company has achieved multiple milestones related to its Phase 2 trial of urcosimod for treatment of neuropathic corneal pain.

On April 30, OKYO announced plans to end the trial early to analyze the data from the patients who had completed the trial, with the goal of accelerating its clinical development and expanding the program. Supporting the decision was the fact that urcosimod had previously demonstrated safety in OKYO’s completed Phase 2 trial of the candidate to treat patients with dry eye disease.

The next day, news broke that the FDA granted urcosimod fast track designation for the treatment of neuropathic corneal pain. OKYO’s stock price reached US$1.57 on May 1.

On July 17, OKYO posted strong top-line data from its Phase 2 clinical trial, and stated it is planning a meeting with the FDA to discuss next steps for its lead drug candidate. The following day, OKYO received US$1.9 million in non-dilutive funding to support its clinical development of urcosimod.

Shares of OKYO hit a year-to-date high of US$3.17 on August 5.

4. IO Biotech (NASDAQ:IOBT)

Year-to-date gain: 129.47 percent
Market cap: US$144.28 million
Share price: US$2.16

IO Biotech is a clinical-stage biopharmaceutical company developing immune-modulating therapeutic cancer vaccines based on its T-win technology platform, designed to activate T cells to target both tumor cells and the immune-suppressive cells. The company’s lead cancer vaccine candidate IO102-IO103, which has the brand name Cylembio, is currently in clinical trials.

The FDA granted breakthrough therapy designation to IO102-IO103 when used in combination with Merck’s (NYSE:MRK) anti-PD-1 therapy KEYTRUDA for the treatment of advanced melanoma based on positive Phase 1/2 first line metastatic melanoma data.

At the start of the year, IO Biotech completed enrollment in its Phase 2 trial of IO102-IO103 with KEYTRUDA as a treatment given before and after surgery for resectable melanoma or head and neck cancer.

On February 4, the company published results from a preclinical study of its second immune-modulatory therapeutic cancer vaccine candidate, IO112, targeting arginase 1, which plays a key role in immune suppression.

In mid-March, IO Biotech was named to Fast Company’s list of the World’s Most Innovative Companies of 2025. The following month, the company presented new preclinical data for its lead candidate IO102-IO103 as well as IO170, which targets Transforming Growth Factor beta.

In its Q1 2025 financial results and business highlights released on May 14, IO Biotech shared that a readout of primary endpoint data from its pivotal Phase 3 trial of its lead investigational therapeutic cancer vaccine in patients with advanced melanoma is expected in the third quarter of 2025.

Shares of IO Biotech reached a year-to-date high of US$2.40 on July 28.

5. Spero Therapeutics (NASDAQ:SPRO)

Year-to-date gain: 110.95 percent
Market cap: US$124.12 million
Share price: US$2.22

Spero Therapeutics is developing novel treatments for rare diseases and multi-drug resistant bacterial infections with high unmet need. The company’s lead drug candidate is tebipenem pivoxil hydrobromide (HBr), a late-stage development asset developed in collaboration with pharma giant GSK (NYSE:GSK) to treat complicated urinary tract infections (cUTIs), including pyelonephritis.

Spero has an exclusive license agreement with GSK for the development and commercialization of the drug candidate in all ex-Asia markets. The FDA has granted tebipenem HBr qualified infectious disease product and fast track designations.

Shares in Spero traded below US$1.00 for much of the first half of 2025. However, the stock’s value surged 245 percent on May 28 to reach US$2.35 per share after Spero reported that its Phase 3 trial evaluating tebipenem HBr for treating cUTIs met its primary endpoint and stopped early for efficacy. GSK plans to include the findings in a filing to the FDA during H2.

Spero shares reached a year-to-date high of US$3.04 on July 9.

Securities Disclosure: I, Melissa Pistilli, hold no direct investment interest in any company mentioned in this article.

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Keith Weiner, founder and CEO of Monetary Metals, discusses gold and silver’s performance so far this year and shares his outlook for the rest of 2025.

He also explains what makes today’s gold bull market different than those seen in prior years.

Securities Disclosure: I, Charlotte McLeod, hold no direct investment interest in any company mentioned in this article.

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Osisko Metals Incorporated (the ‘ Company or ‘ Osisko Metals ‘) ( TSX-V: OM ; OTCQX: OMZNF ; FRANKFURT: 0B51 ) is pleased to announce new drill results from the Gaspé Copper Project, located in the Gaspé Peninsula of Eastern Québec.

Osisko Metals Chief Executive Officer Robert Wares commented: ‘ Drill results at Gaspé Copper continue to exceed expectations. These new data expand the deposit further south and at depth with drill holes 30-1092 and 30-872, located respectively 230 metres and 440 metres south of the 2024 Mineral Resource Estimate (‘MRE’) model. Additional holes are planned in this resource expansion target area in the coming months over a surface of 450 metres by 550 metres, which we believe will add significant new tonnage to the MRE update, planned for Q1 2026.

New analytical results are presented below (see Table 1), including 20 mineralized intercepts from 7 new drill holes. Infill intercepts are located inside the 2024 MRE model ( see November 14, 2024 news release ), and are focused on upgrading inferred mineral resources to measured or indicated categories, as applicable. Expansion intercepts are located outside the 2024 MRE model and may potentially lead to additional resources that will be classified appropriately within the next MRE update. Some of the reported intercepts have contiguous shallower infill as well as deeper expansion (noted on Table 1 below as ‘Both**’). Maps showing hole locations are available at www.osiskometals.com .

Highlights:

  • Drill hole 30-1096
    • 730.7 metres averaging 0.29% Cu (infill and expansion)
  • Drill hole 30-1085
    • 219.0 metres averaging 0.41% Cu (infill)
    • 754.5 metres averaging 0.24% Cu (infill and expansion)
  • Drill hole 30-1092
    • 331.5 metres averaging 0.37% Cu (expansion)
  • Drill hole 30-1095
    • 309.5 metres averaging 0.26% Cu (infill)
  • Drill hole 30-1098
    • 115.0 metres averaging 0.29% Cu (infill)
    • 124.5 metres averaging 0.20% Cu (expansion)
  • Drill hole 30-1099
    • 614.7 metres averaging 0.23% Cu (infill and expansion)
  • Drill hole 30-0872
    • 92.1 metres averaging 0.24% Cu (expansion)
    • 47.2 metres averaging 1.14% Cu (expansion)

Table 1: Infill and Expansion Drilling Results

DDH No. From (m) To (m) Length (m) Cu % Ag g/t Mo % CuEq* Type**
30-0872 167.6 259.7 92.1 0.24 3.05 0.25 Expansion
And 342.0 389.2 47.2 1.14 11.84 1.22 Expansion
30-1085 3.0 222.0 219.0 0.41 2.79 0.44 Infill
And 355.5 1110 754.5 0.24 1.63 0.019 0.32 Both
(including) 355.5 763.3 407.8 0.21 1.49 0.020 0.30 Infill
(including) 763.3 1110.0 346.7 0.27 1.79 0.019 0.36 Expansion
30-1092 15.0 346.5 331.5 0.37 3.21 0.39 Expansion
30-1095 15.0 43.0 28.0 0.22 1.75 0.23 Infill
And 57.0 366.5 309.5 0.26 2.11 0.007 0.30 Infill
And 425.9 482.0 56.1 0.23 1.70 0.24 Expansion
And 524.7 550.5 21.9 0.42 2.04 0.43 Expansion
30-1096 27.0 78.0 51.0 0.21 1.40 0.22 Infill
And 129.0 177.0 48.0 0.17 1.20 0.18 Infill
And 331.5 1062.2 730.7 0.29 1.60 0.032 0.42 Both
(including) 331.5 727.5 396.0 0.21 1.45 0.032 0.34 Infill
(including) 727.5 1062.2 334.7 0.39 1.79 0.032 0.52 Expansion
30-1098 36.0 141.0 104.5 0.20 2.25 0.21 Infill
And 255.0 288.0 33.0 0.21 1.18 0.22 Infill
And 330.0 445.5 115.0 0.29 2.18 0.017 0.36 Infill
And 606.0 730.5 124.5 0.20 1.57 0.014 0.26 Expansion
And 753.0 813.0 60.0 0.35 2.88 0.006 0.39 Expansion
30-1099 31.5 66.0 34.5 0.22 1.08 0.23 Infill
And 105.3 720.0 614.7 0.23 1.59 0.016 0.30 Both
(including) 105.3 578.0 472.7 0.23 1.61 0.017 0.30 Infill
(including) 578.0 720.0 142.0 0.23 1.52 0.015 0.30 Expansion
And 862.2 1000.5 138.0 0.13 1.01 0.028 0.24 Expansion

* See explanatory notes below on copper equivalent values and Quality Assurance / Quality Control.
** ‘Both’ indicates drill holes that have contiguous shallower infill as well as deeper expansion intercepts.

Discussion

Drill hole 30-0872 was an old Noranda hole from the 1990s from which core was recovered and analyzed. The hole is located 440 metres south of the southern limit of 2024 MRE model and returned 92.1 metres averaging 0.24% Cu and 3.05 g/t Ag followed by a higher grade second intercept of 47.2 metres averaging 1.14% Cu and 11.8 g/t Ag (at the level of the C Zone skarn horizon), extending mineralization to a vertical depth of 390 metres. The first intercept starts at a depth of 168 metres and the overlying stratigraphy (Indian Cove hornfels) is unmineralized, but this waste material may be included as necessary strip in the next Whittle pit shell.

Drill hole 30-1085, located on top of Copper Mountain near the central part of the 2024 MRE model, intersected 219.0 metres averaging 0.41% Cu and 2.79 g/t Ag (infill), followed by a second intercept (starting 130 metres deeper) of 754.5 metres averaging 0.24% Cu, 1.63 g/t Ag and 0.019% Mo (both infill and expansion at depth).This hole extends mineralization near the centre of the deposit to a vertical depth of 1110 metres.

Drill hole 30-1092 is located 230 metres south of the southern limit of 2024 MRE model and returned 331.5 metres averaging 0.37% Cu and 3.21 g/t Ag (from surface down to the P4 stratigraphic level below the C Zone). This hole is located approximately 15 metres west of previously-reported hole 30-1067, which had failed to drill through a pillar of the B Zone.

Drill hole 30-1095, located in the south-central part of the 2024 MRE model, intersected 309.5 metres averaging 0.26% Cu and 2.11 g/t Ag (infill). This was followed by 56.1 metres averaging 0.23% Cu and 1.70 g/t Ag and then by another 21.9 metres averaging 0.42% Cu and 2.04 g/t Ag (both expansion), extending mineralization to a vertical depth of 550 metres.

Drill hole 30-1096, located in the central part of the 2024 MRE model, intersected two short (51 and 48 metre-long) mineralized zones, followed by 730.7 metres averaging 0.29% Cu, 1.60 g/t Ag, and 0.032% Mo (0.42% CuEq). The latter includes an expansion lower intercept, below the base of the 2024 MRE model, of 334.7 metres averaging 0.39% Cu, 1.79 g/t Ag, and 0.032% Mo (0.52% CuEq). This hole extends mineralization to a vertical depth of 1062 metres.

Drill hole 30-1098, located near the western margin of the 2024 MRE model, intersected 104.5 metres averaging 0.20% Cu and 2.25 g/t Ag (infill), followed by 115.0 metres averaging 0.29% Cu and 2.18 g/t Ag (infill). This was followed by 124.0 metres averaging 0.20% Cu and 1.57 g/t Ag and then by another 60.0 metres averaging 0.35% Cu and 2.88 g/t Ag (both expansion), extending mineralization to a vertical depth of 813 metres.

Drill hole 30-1099, located near the central part of the 2024 MRE model, adjacent to the Copper Mountain pit, intersected a short (34-metre-long) mineralized zone followed by 614.7 metres averaging 0.23% Cu, 1.59 g/t Ag, and 0.016% Mo (both infill and expansion), followed by a third intersection of 138 metres that averaged 0.13% Cu, 1.01 g/t Ag, and 0.028% Mo (expansion), extending mineralization in the porphyry core of the deposit to a vertical depth of 1000 metres.

Mineralization at Gaspé Copper is of porphyry copper/skarn type and occurs as disseminations and stockworks of chalcopyrite with pyrite or pyrrhotite and minor bornite and molybdenite. At least five retrograde vein/stockwork mineralizing events have been recognized at Copper Mountain, which overprint earlier prograde skarn and porcellanite-hosted mineralization throughout the Gaspé Copper system. Porcellanite is a historical mining term used to describe bleached, pale green to white potassic-altered hornfels. Subvertical stockwork mineralization dominates at Copper Mountain whereas prograde bedding-replacement mineralization, that is mostly stratigraphically controlled, dominates in the area of Needle Mountain, Needle East, and Copper Brook. High molybdenum grades (up to 0.5% Mo) were locally obtained in both the C Zone and E Zone skarns away from Copper Mountain.

The 2022 to 2024 Osisko Metals drill programs were focused on defining open-pit resources within the Copper Mountain stockwork mineralization ( see May 6, 2024 MRE press release ). Extending the resource model south of Copper Mountain into the poorly-drilled prograde skarn/porcellanite portion of the system subsequently led to a significantly increased resource, mostly in the Inferred category ( see November 14, 2024 MRE press release ).

The current drill program is designed to convert the November 2024 MRE to Measured and Indicated categories, as well as test the expansion of the system deeper into the stratigraphy and laterally to the south and southwest towards Needle East and Needle Mountain respectively. The November 2024 MRE was limited at depth to the base of the L1 skarn horizon (C Zone), and all mineralized intersections below this horizon represent potential depth extensions to the deposit, to be included in the next scheduled MRE update in Q1 2026.

All holes are being drilled sub-vertically into the altered calcareous stratigraphy which dips 20 to 25 degrees to the north. The L1 (C Zone) the L2 (E Zone) skarn/marble horizons were intersected in most holes, as well as intervening porcellanites that host the bulk of the disseminated copper mineralization.

Table 2: Drill hole locations

DDH No. Azimuth (°) Dip (°) Length (m) UTM E UTM N Elevation
30-0872 0.00 -90.00 594.3 316531.1 5425181.2 706.3
30-1085 0.00 -90.00 1110.0 316020.0 5426400.0 742.5
30-1092 0.00 -90.00 741.0 316342.0 5425425.0 609.0
30-1095 0.00 -90.00 696.0 316409.1 5425733.0 572.8
30-1096 0.00 -90.00 1069.0 316198.0 5426305.0 753.3
30-1098 0.00 -90.00 861.0 316034.0 5425948.0 600.5
30-1099 0.00 -90.00 1041.0 315700.0 5426462.0 603.7

Explanatory note regarding copper-equivalent grades

Copper Equivalent grades are expressed for purposes of simplicity and are calculated taking into account: 1) metal grades; 2) estimated long-term prices of metals: US$4.25/lb copper, $20.00/lb molybdenum and US$24/oz silver; 3) estimated recoveries of 92%, 70% and 70% for Cu, Mo and Ag respectively; and 4) net smelter return value of metals as percentage of the price, estimated at 86.5%, 90.7% and 75.0% for Cu, Mo and Ag respectively.

Qualified Person

The scientific and technical content of this news release has been reviewed and approved by Mr. Bernard-Olivier Martel, P. Geo. (OGQ 492), an independent ‘qualified person’ as defined by National Instrument 43-101 – Standards of Disclosure for Mineral Projects (‘NI 43-101’).

Quality Assurance / Quality Control

Mineralized intervals reported herein are calculated using an average 0.12% CuEq lower cut-off over contiguous 20-metre intersections (shorter intervals as the case may be at the upper and lower limits of reported intervals). Intervals of 20 metres or less are not reported unless indicating significantly higher grades . True widths are estimated at 90 – 92% of the reported core length intervals.

Osisko Metals adheres to a strict QA/QC program for core handling, sampling, sample transportation and analyses, including insertion of blanks and standards in the sample stream. Drill core is drilled in HQ or NQ diameter and securely transported to its core processing facility on site, where it is logged, cut and sampled. Samples selected for assay are sealed and shipped to ALS Canada Ltd.’s preparation facility in Sudbury. Sample preparation details (code PREP-31DH) are available on the ALS Canada website. Pulps are analyzed at the ALS Canada Ltd. facility in North Vancouver, BC. All samples are analyzed by four acid digestion followed by both ICP-AES and ICP-MS for Cu, Mo and Ag.

Option Grant

The Company announces that, effective August 12, 2025, it has granted to an employee of the Company an aggregate of 125,000 stock options (‘Options’) pursuant to the Osisko Metals omnibus equity incentive plan.

The Options have an exercise price of $0.44 per share and a five-year term from the date of grant, and vest annually in equal thirds beginning on the first anniversary of the date of grant.

About Osisko Metals

Osisko Metals Incorporated is a Canadian exploration and development company creating value in the critical metals sector, with a focus on copper and zinc. The Company acquired a 100% interest in the past-producing Gaspé Copper mine from Glencore Canada Corporation in July 2023. The Gaspé Copper mine is located near Murdochville in Québec s Gaspé Peninsula. The Company is currently focused on resource expansion of the Gaspé Copper system, with current Indicated Mineral Resources of 824 Mt averaging 0.34% CuEq and Inferred Mineral Resources of 670 Mt averaging 0.38% CuEq (in compliance with NI 43-101). For more information, see Osisko Metals’ November 14, 2024 news release entitled ‘Osisko Metals Announces Significant Increase in Mineral Resource at Gaspé Copper’. Gaspé Copper hosts the largest undeveloped copper resource in eastern North America, strategically located near existing infrastructure in the mining-friendly province of Québec.

In addition to the Gaspé Copper project, the Company is working with Appian Capital Advisory LLP through the Pine Point Mining Limited joint venture to advance one of Canada s largest past-producing zinc mining camps, the Pine Point project, located in the Northwest Territories. The current mineral resource estimate for the Pine Point project consists of Indicated Mineral Resources of 49.5 Mt averaging 5.52% ZnEq and Inferred Mineral Resources of 8.3 Mt averaging 5.64% ZnEq (in compliance with NI 43-101). For more information, see Osisko Metals June 25, 2024 news release entitled ‘Osisko Metals releases Pine Point mineral resource estimate: 49.5 million tonnes of indicated resources at 5.52% ZnEq’. The Pine Point project is located on the south shore of Great Slave Lake, NWT, close to infrastructure, with paved road access, an electrical substation and 100 kilometers of viable haul roads.

For further information on this news release, visit www.osiskometals.com or contact:

Don Njegovan, President
Email: info@osiskometals.com
Phone: (416) 500-4129

Cautionary Statement on Forward-Looking Information

This news release contains ‘forward-looking information’ within the meaning of applicable Canadian securities legislation based on expectations, estimates and projections as at the date of this news release. Any statement that involves predictions, expectations, interpretations, beliefs, plans, projections, objectives, assumptions, future events or performance (often, but not always, using phrases such as ‘expects’, or ‘does not expect’, ‘is expected’, ‘interpreted’, ‘management’s view’, ‘anticipates’ or ‘does not anticipate’, ‘plans’, ‘budget’, ‘scheduled’, ‘forecasts’, ‘estimates’, ‘potential’, ‘feasibility’, ‘believes’ or ‘intends’ or variations of such words and phrases or stating that certain actions, events or results ‘may’ or ‘could’, ‘would’, ‘might’ or ‘will’ be taken, occur or be achieved) are not statements of historical fact and may be forward-looking information and are intended to identify forward-looking information. This news release contains forward-looking information pertaining to, among other things: the tax treatment of the FT Units; the timing of incurring the Qualifying Expenditures and the renunciation of the Qualifying Expenditures; the ability to advance Gaspé Copper to a construction decision (if at all); the ability to increase the Company’s trading liquidity and enhance its capital markets presence; the potential re-rating of the Company; the ability for the Company to unlock the full potential of its assets and achieve success; the ability for the Company to create value for its shareholders; the advancement of the Pine Point project; the anticipated resource expansion of the Gaspé Copper system and Gaspé Copper hosting the largest undeveloped copper resource in eastern North America.

Forward-looking information is not a guarantee of future performance and is based upon a number of estimates and assumptions of management, in light of management’s experience and perception of trends, current conditions and expected developments, as well as other factors that management believes to be relevant and reasonable in the circumstances, including, without limitation, assumptions about: the ability of exploration results, including drilling, to accurately predict mineralization; errors in geological modelling; insufficient data; equity and debt capital markets; future spot prices of copper and zinc; the timing and results of exploration and drilling programs; the accuracy of mineral resource estimates; production costs; political and regulatory stability; the receipt of governmental and third party approvals; licenses and permits being received on favourable terms; sustained labour stability; stability in financial and capital markets; availability of mining equipment and positive relations with local communities and groups. Forward-looking information involves risks, uncertainties and other factors that could cause actual events, results, performance, prospects and opportunities to differ materially from those expressed or implied by such forward-looking information. Factors that could cause actual results to differ materially from such forward-looking information are set out in the Company’s public disclosure record on SEDAR+ (www.sedarplus.ca) under Osisko Metals’ issuer profile. Although the Company believes that the assumptions and factors used in preparing the forward-looking information in this news release are reasonable, undue reliance should not be placed on such information, which only applies as of the date of this news release, and no assurance can be given that such events will occur in the disclosed time frames or at all. The Company disclaims any intention or obligation to update or revise any forward-looking information, whether as a result of new information, future events or otherwise, other than as required by law.

Neither the TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accept responsibility for the adequacy or accuracy of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.

Photos accompanying this announcement are available at:
https://www.globenewswire.com/NewsRoom/AttachmentNg/f12ebf89-5e37-4f45-86a2-3476365db1e2
https://www.globenewswire.com/NewsRoom/AttachmentNg/2a67e753-d0a2-4e74-8717-d7ee5bf555b7

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